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Article

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.

Molecular cell - 5 Sept 2008

Li Gang, Alt Frederick W, Cheng Hwei-Ling, Brush James W, Goff Peter H, Murphy Mike M, Franco Sonia, Zhang Yu, Zha Shan

Abstract excerpt

Mutations in XLF/Cernunnos (XLF) cause lymphocytopenia in humans, and various studies suggest an XLF role in classical nonhomologous end joining (C-NHEJ). We now find that XLF-deficient mouse embryonic fibroblasts are ionizing radiation (IR) sensitive and severely impaired for ability to support V(D)J recombination. Yet mature lymphocyte numbers in XLF-deficient mice are only modestly decreased. Moreover,...

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Source

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Identifiers

PMID: 18775323
DOI: 10.1016/j.molcel.2008.07.017
PMCID: PMC2630261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.PMID 18775323Read ↗

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XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Semantic proximity Read ↗

Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repairSemantic proximity Read ↗

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.Semantic proximity Read ↗

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Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and HumansSemantic proximity Read ↗

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytesSemantic proximity Read ↗

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XLF deficiency results in reduced N-nucleotide addition during V(D)J recombinationSemantic proximity Read ↗

An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development.Semantic proximity Read ↗

Interplay between Cernunnos-XLF and Nonhomologous End-joining Proteins at DNA Ends in the CellSemantic proximity Read ↗

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