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Article

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.

Cell - 27 Jan 2006

Buck Dietke, Malivert Laurent, de Chasseval Régina, Barraud Anne, Fondanèche Marie-Claude, Sanal Ozden, Plebani Alessandro, Stéphan Jean-Louis, Hufnagel Markus, le Deist Françoise, Fischer Alain, Durandy Anne, de Villartay Jean-Pierre, Revy Patrick

Abstract excerpt

DNA double-strand breaks (DSBs) occur at random upon genotoxic stresses and represent obligatory intermediates during physiological DNA rearrangement events such as the V(D)J recombination in the immune system. DSBs, which are among the most toxic DNA lesions, are preferentially repaired by the nonhomologous end-joining (NHEJ) pathway in higher eukaryotes. Failure to properly repair DSBs results in genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16439204
DOI: 10.1016/j.cell.2005.12.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.PMID 16439204Read ↗

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