Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.

The Journal of biological chemistry - 8 Dec 2006

Hentges Pierre, Ahnesorg Peter, Pitcher Robert S, Bruce Chris K, Kysela Boris, Green Andrew J, Bianchi Julie, Wilson Thomas E, Jackson Stephen P, Doherty Aidan J

Abstract excerpt

Non-homologous end-joining is a major pathway of DNA double-strand break repair in mammalian cells, deficiency in which confers radiosensitivity and immune deficiency at the whole organism level. A core protein complex comprising the Ku70/80 heterodimer together with a complex between DNA ligase IV and XRCC4 is conserved throughout eukaryotes and assembles at double-strand breaks to mediate ligation of broken DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Fungal
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Multiprotein Complexes

Share to Neurospora crassa

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Yeasts

Source

Identifiers

PMID: 17038309
DOI: 10.1074/jbc.M608727200

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.PMID 17038309Read ↗

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Semantic proximity Read ↗

Interplay between Cernunnos-XLF and Nonhomologous End-joining Proteins at DNA Ends in the CellSemantic proximity Read ↗

Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1Semantic proximity Read ↗

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining.Semantic proximity Read ↗

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.Semantic proximity Read ↗

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.Semantic proximity Read ↗

Crystal structure of human XLF: a twist in nonhomologous DNA end-joining.Semantic proximity Read ↗

Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF.Semantic proximity Read ↗

Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity.Semantic proximity Read ↗

APLF promotes the assembly and activity of non-homologous end joining protein complexes.Semantic proximity Read ↗

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytesSemantic proximity Read ↗

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.