Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and Humans

4 Dec 2012

Abstract excerpt

Cernunnos is a DNA repair factor of the nonhomologous end-joining machinery. Its deficiency in humans causes radiosensitive severe combined immune deficiency (SCID) with microcephaly, characterized in part by a profound lymphopenia. In contrast to the human condition, the immune system of Cernunnos knockout (KO) mice is not overwhelmingly affected. In particular, Cernunnos is dispensable during V(D)J...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23207905
DOI: 10.1128/mcb.01057-12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and HumansPMID 23207905Read ↗

Cernunnos deficiency: Further delineation in 5 Egyptian patients.Semantic proximity Read ↗

Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesisSemantic proximity Read ↗

Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1Semantic proximity Read ↗

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.Semantic proximity Read ↗

Novel XLF/Cernunnos mutation linked to severe combined immunodeficiency, microcephaly and abnormal T and B cell receptor repertoiresSemantic proximity Read ↗

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.Semantic proximity Read ↗

Base Excision Repair in the Immune System: Small DNA Lesions With Big ConsequencesSemantic proximity Read ↗

Cernunnos deficiency: a case report.Semantic proximity Read ↗

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.Semantic proximity Read ↗

Primary immunodeficiency syndromes associated with defective DNA double-strand break repairSemantic proximity Read ↗

Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research.Semantic proximity Read ↗

Immunodeficiency associated with DNA repair defectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.