XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.

doi:10.1016/j.cell.2005.12.031

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Article

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.

Cell - 27 Jan 2006

Ahnesorg Peter, Smith Philippa, Jackson Stephen P

Abstract excerpt

DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand break repair in mammalian cells, and defects in it cause radiosensitivity at the cellular and whole-organism levels. Central to NHEJ is the protein complex containing DNA Ligase IV and XRCC4. By searching for additional XRCC4-interacting factors, we identified a previously uncharacterized 33 kDa protein, XRCC4-like factor (XLF,...

Topics

Amino Acid Sequence
Animals
Cell Line
Consensus Sequence
DNA Ligase ATP
DNA Ligases
DNA Repair
DNA Repair Enzymes
DNA-Binding Proteins
Down-Regulation
Humans
Molecular Sequence Data
Mutation
Nuclear Proteins
Radiation Tolerance
Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 16439205
DOI: 10.1016/j.cell.2005.12.031

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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