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Article

Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.

Aging - 7 Dec 2020

Castañeda-Zegarra Sergio, Zhang Qindong, Alirezaylavasani Amin, Fernandez-Berrocal Marion, Yao Rouan, Oksenych Valentyn

Abstract excerpt

Non-homologous end-joining (NHEJ) is a DNA repair pathway required to detect, process, and ligate DNA double-stranded breaks (DSBs) throughout the cell cycle. The NHEJ pathway is necessary for V(D)J recombination in developing B and T lymphocytes. During NHEJ, Ku70 and Ku80 form a heterodimer that recognizes DSBs and promotes recruitment and function of downstream factors PAXX, MRI, DNA-PKcs, Artemis, XLF, XRCC4,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33289702
DOI: 10.18632/aging.202346
PMCID: PMC7762521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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