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Article

PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.

Cell death and differentiation - 1 Feb 2018

Abramowski Vincent, Etienne Olivier, Elsaid Ramy, Yang Junjie, Berland Aurélie, Kermasson Laetitia, Roch Benoit, Musilli Stefania, Moussu Jean-Paul, Lipson-Ruffert Karelia, Revy Patrick, Cumano Ana, Boussin François D, de Villartay Jean-Pierre

Abstract excerpt

The repair of DNA double-stranded breaks (DNAdsb) through non-homologous end joining (NHEJ) is a prerequisite for the proper development of the central nervous system and the adaptive immune system. Yet, mice with Xlf or PAXX loss of function are viable and present with very mild immune phenotypes, although their lymphoid cells are sensitive to ionizing radiation attesting for the role of these factors in NHEJ....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA End-Joining Repair

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Source

Open in PubMed Open full text

Identifiers

PMID: 29077092
DOI: 10.1038/cdd.2017.184
PMCID: PMC5762856

Genes

PAXX
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.PMID 29077092Read ↗

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