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Article

Regulation of Ubx expression by epigenetic enhancer silencing in response to Ubx levels and genetic variation.

PLoS genetics - 1 Sept 2009

Crickmore Michael A, Ranade Vikram, Mann Richard S

Abstract excerpt

For gene products that must be present in cells at defined concentrations, expression levels must be tightly controlled to ensure robustness against environmental, genetic, and developmental noise. By studying the regulation of the concentration-sensitive Drosophila melanogaster Hox gene Ultrabithorax (Ubx), we found that Ubx enhancer activities respond to both increases in Ubx levels and genetic background....

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Identifiers

PMID: 19730678
DOI: 10.1371/journal.pgen.1000633
PMCID: PMC2726431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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