Article
Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2008
Kumar Amit, Lualdi Margaret, Lewandoski Mark, Kuehn Michael R
Abstract excerpt
Nodal signaling is a critical regulator of multiple aspects of early vertebrate development including asymmetry along the left/right (LR) axis. To study Nodal function occurring specifically in the postgastrulation embryo, we have used Cre/loxP based conditional mutagenesis. A floxed allele of Nodal was generated and shown to have wild-type function. This allele was then used in conjunction with the T-Cre line,...
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