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Article

Transgenerational effect of fetal programming on vascular phenotype and reactivity in endothelial nitric oxide synthase knockout mouse model.

American journal of obstetrics and gynecology - 1 Sept 2008

Costantine Maged M, Ghulmiyyah Labib M, Tamayo Esther, Hankins Gary D V, Saade George R, Longo Monica

Abstract excerpt

OBJECTIVE: The objective of the study was to investigate the transgenerational effect of fetal vascular programming STUDY DESIGN: Homozygous NOS3 knockout and wild type controls (NOS3+/+WT) were cross-bred to obtain heterozygous offspring that developed in (KO-/-) mothers lacking a functional NOS3 (KOM) vs wild-type control mothers (KOP). The first-generation KOM(+/-) and KOP(+/-) female mice were then bred with...

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Source

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Identifiers

PMID: 18771972
DOI: 10.1016/j.ajog.2008.07.002
PMCID: PMC2796619

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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