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Nitric oxide and the cardiovascular system: cell activation, vascular reactivity and genetic variant.

Arquivos brasileiros de cardiologia - 1 Jan 2011

Dias Rodrigo Gonçalves, Negrão Carlos Eduardo, Krieger Marta Helena

Abstract excerpt

Nitric oxide (NO), primarily identified as an endothelium-derived relaxing factor, is a free radical that signals different biological processes. The identification of NO synthase (NOS) isoforms and the subsequent characterization of the mechanisms of cell activation of the enzymes permitted the partial understanding of both the physiological interactions and of the mechanisms of the diseases in which NO is...

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PMID: 21308339

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