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Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease

1 Aug 2008

Abstract excerpt

Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant defences and NO generation underlie the genesis of endothelial dysfunction and operate as part of the normal processes of developmental plasticity regulating the induction of phenotype in the offspring. Female Wistar...

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PMID: 18669533
DOI: 10.1113/jphysiol.2008.156976

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