Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data.

doi:10.1007/s00439-016-1694-2

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Article

Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data.

Human genetics - 1 Aug 2016

Goncalves Adriana, Makalo Pateh, Joof Hassan, Burr Sarah, Ramadhani Athumani, Massae Patrick, Malisa Aiweda, Mtuy Tara, Derrick Tamsyn, Last Anna R, Nabicassa Meno, Cassama Eunice, Houghton Joanna, Palmer Christine D, Pickering Harry, Burton Matthew J, Mabey David C W, Bailey Robin L, Goodier Martin R, Holland Martin J, Roberts Chrissy H

Abstract excerpt

NKG2C is an activating receptor that is preferentially expressed on natural killer (NK) cells. The gene encoding NKG2C (killer cell lectin-like receptor C2, KLRC2) is present at different copy numbers in the genomes of different individuals. Deletion at the NKG2C locus was investigated in a case-control study of 1522 individuals indigenous to East- and West-Africa and the association with the ocular Chlamydia...

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PMID: 27312142
DOI: 10.1007/s00439-016-1694-2
PMCID: PMC4947484

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KLRC2

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