Article
SNPs rs4656317 and rs12071048 located within an enhancer in FCGR3A are in strong linkage disequilibrium with rs396991 and influence NK cell-mediated ADCC by transcriptional regulation.
Human immunology - 1 Oct 2016
Oboshi Wataru, Watanabe Toru, Yukimasa Nobuyasu, Ueno Ichiro, Aki Kensaku, Tada Tomoki, Hosoi Eiji
Abstract excerpt
CD16 receptors are mainly expresses on the surface of NK cells and mediate antibody-dependent cellular cytotoxicity (ADCC). The authors previously reported that NK cell-mediated ADCC is influenced by the single nucleotide polymorphism (SNP) rs396991 (T>G; F158V), and the structure and expression levels of CD16 differed among these genotypes. The authors examined haplotype frequency distributions among rs396991...
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