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Article

Aging in check.

Science of aging knowledge environment : SAGE KE - 5 Apr 2006

Dai Wei, Wang Xiaoxing

Abstract excerpt

The spindle checkpoint monitors the interaction between spindle microtubules and kinetochores to prevent precocious entry into anaphase, delaying this stage of mitosis until all condensed chromosomes have been attached to the mitotic spindle in a bi-oriented manner (so that the two kinetochores associated with a pair of sister chromatids are oriented toward opposite poles of the spindle). In addition to conserved...

Topics

Aging
Aging, Premature
Aneuploidy
Animals
Cell Cycle Proteins
Cellular Senescence
Chromosomal Instability
Genes, cdc
Genes, p53
Humans
Mice
Mitosis
Nuclear Matrix-Associated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleocytoplasmic Transport Proteins

Phenotype

Poly-ADP-Ribose Binding Proteins

Source

Identifiers

PMID: 16600919
DOI: 10.1126/sageke.2006.7.pe9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16600919-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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