Article
Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses.
Journal of virology - 1 Feb 2010
Mueller Scott N, Langley William A, Carnero Elena, García-Sastre Adolfo, Ahmed Rafi
Abstract excerpt
The generation of vaccines that induce long-lived protective immunity against influenza virus infections remains a challenging goal. Ideally, vaccines should elicit effective humoral and cellular immunity to protect an individual from infection or disease. Cross-reactive T- and B-cell responses that are elicited by live virus infections may provide such broad protection. Optimal induction of T-cell responses...
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