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Article

Development of a live-attenuated influenza B DeltaNS1 intranasal vaccine candidate.

Vaccine - 11 May 2009

Wressnigg Nina, Voss Daniel, Wolff Thorsten, Romanova Julia, Ruthsatz Tanja, Mayerhofer Ines, Reiter Manfred, Nakowitsch Sabine, Humer Johannes, Morokutti Alexander, Muster Thomas, Egorov Andrej, Kittel Christian

Abstract excerpt

We discovered a unique, single amino acid mutation in the influenza B M1 protein promoting viral growth of NS1 truncation mutants in Vero cells. Due to this mutation, we were able to generate an influenza B virus lacking the complete NS1 open reading frame (DeltaNS1-B virus) by reverse genetics, which was growing to titers of 8log(10)TCID(50)/ml in a Vero cell culture-based micro-carrier fermenter. The DeltaNS1-B...

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Identifiers

PMID: 19366569
DOI: 10.1016/j.vaccine.2009.02.087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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