Article
NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis.
Neurobiology of disease - 1 Aug 2023
Yang Biying, Pan Jingrui, Zhang Xiao-Ni, Wang Hongxuan, He Lei, Rong Xiaoming, Li Xiangpen, Peng Ying
Abstract excerpt
The progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS) is caused by a decline in motor neuron function, resulting in worsened motor impairments, malnutrition, respiratory failure and mortality, and there is a lack of effective clinical treatments. The exact mechanism of motor neuronal degeneration remains unclear. Previously, we reported that ferroptosis, which is characterized by the...
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