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Article

Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.

Neuroscience - 9 Feb 2007

Chi L, Ke Y, Luo C, Gozal D, Liu R

Abstract excerpt

The mechanism of selective and age-dependent motor neuron degeneration in human amyotrophic lateral sclerosis (ALS) has not been defined and the role of glutathione (GSH) in association with motor neuron death remains largely unknown. A motor neuron-like cell culture system and a transgenic mouse model were used to study the effect of cellular GSH alteration on motor neuron cell death. Exposure of NSC34 motor...

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Source

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Identifiers

PMID: 17150307
DOI: 10.1016/j.neuroscience.2006.09.064
PMCID: PMC1944995

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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