Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.

Neuroscience - 9 Feb 2007

Chi L, Ke Y, Luo C, Gozal D, Liu R

Abstract excerpt

The mechanism of selective and age-dependent motor neuron degeneration in human amyotrophic lateral sclerosis (ALS) has not been defined and the role of glutathione (GSH) in association with motor neuron death remains largely unknown. A motor neuron-like cell culture system and a transgenic mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Glutathione
Share to Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Degeneration

Share to Reactive Oxygen Species

Share to Spinal Cord

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 17150307
DOI: 10.1016/j.neuroscience.2006.09.064
PMCID: PMC1944995

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17150307-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.PMID 17150307Read ↗

DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.Semantic proximity Read ↗

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target.Semantic proximity Read ↗

Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice.Semantic proximity Read ↗

The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice.Semantic proximity Read ↗

NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis.Semantic proximity Read ↗

β-Amyloid and Glutathione Dysregulation Cooperatively Drive Lipid Peroxidation and Ferroptosis in Neuron-Like CellsSemantic proximity Read ↗

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration.Semantic proximity Read ↗

Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice.Semantic proximity Read ↗

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.Semantic proximity Read ↗

EPI-589, a redox-active neuroprotectant, potently protects cultured cells from oxidative stress and alleviates symptomatic and pathological progression of motor neuron disease in the wobbler mouseSemantic proximity Read ↗

Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells.Semantic proximity Read ↗

Insights on aspects of apoptosis in neurodegenerative disorders: a comprehensive reviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.