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Article

Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia.

Biochimica et biophysica acta - 1 Jun 2015

Romero Juan Ignacio, Hanschmann Eva-Maria, Gellert Manuela, Eitner Susanne, Holubiec Mariana Inés, Blanco-Calvo Eduardo, Lillig Christopher Horst, Capani Francisco

Abstract excerpt

BACKGROUND: Thioredoxin (Trx) family proteins are crucial mediators of cell functions via regulation of the thiol redox state of various key proteins and the levels of the intracellular second messenger hydrogen peroxide. Their expression, localization and functions are altered in various pathologies. Here, we have analyzed the impact of Trx family proteins in neuronal development and recovery, following...

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PMID: 25735211
DOI: 10.1016/j.bbagen.2015.02.015

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