Article
Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.
Arthritis and rheumatism - 1 Sept 2008
McArdle Patrick F, Parsa Afshin, Chang Yen-Pei C, Weir Matthew R, O'Connell Jeffery R, Mitchell Braxton D, Shuldiner Alan R
Abstract excerpt
OBJECTIVE: Uric acid is the primary end product of purine metabolism. Increased serum uric acid levels have been associated with gouty arthritis as well as with a variety of cardiovascular-related phenotypes. This study was undertaken to investigate associations between uric acid levels and single-nucleotide polymorphisms (SNPs). METHODS: A 500,000-SNP genome-wide association study of serum uric acid levels was...
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