Article
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
PLoS genetics - 1 Nov 2007
Li Siguang, Sanna Serena, Maschio Andrea, Busonero Fabio, Usala Gianluca, Mulas Antonella, Lai Sandra, Dei Mariano, Orrù Marco, Albai Giuseppe, Bandinelli Stefania, Schlessinger David, Lakatta Edward, Scuteri Angelo, Najjar Samer S, Guralnik Jack, Naitza Silvia, Crisponi Laura, Cao Antonio, Abecasis Gonçalo, Ferrucci Luigi, Uda Manuela, Chen Wei-Min, Nagaraja Ramaiah
Abstract excerpt
High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and...
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