Genotype-based changes in serum uric acid affect blood pressure.

doi:10.1038/ki.2011.414

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Article

Genotype-based changes in serum uric acid affect blood pressure.

Kidney international - 1 Mar 2012

Parsa Afshin, Brown Eric, Weir Matthew R, Fink Jeffrey C, Shuldiner Alan R, Mitchell Braxton D, McArdle Patrick F

Abstract excerpt

Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated. To help define this relationship, we used a controlled setting within a homogeneous Amish community and the Mendelian randomization of a nonsynonymous coding single-nucleotide polymorphism, rs16890979 (Val253Ile), in the SLC2A9 gene. This gene expresses the GLUT9 transporter that...

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PMID: 22189840
DOI: 10.1038/ki.2011.414
PMCID: PMC3640827

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