Article
Multi-domain misfolding: understanding the aggregation pathway of polyglutamine proteins
9 Jul 2009
Abstract excerpt
The polyglutamine (polyQ) diseases consist of nine neurodegenerative diseases in which a polyQ tract expansion leads to protein misfolding and subsequent aggregation. Even when the causative proteins have the same length polyQ tract, there are differences in the severity and age of disease onset which implicate the polyQ flanking sequences as modulators of disease. Recent studies on the polyQ proteins ataxin-1,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.