Article
Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor.
Brain research - 21 Oct 2008
Frassetto Andrea, Zhang Jiaping, Lao Julie Z, White Amanda, Metzger Joseph M, Fong Tung M, Chen Richard Z
Abstract excerpt
We investigated the feeding behavior of mice carrying a non-functional 5-hydroxytryptamine-6 receptor (5-HT6). Homozygous mutant mice on C57BL/6 background were grossly normal and showed normal growth when fed a low-fat chow diet. When fed a high-fat diet, the mutant mice consumed approximately 8% less food while gaining approximately 35% less weight over an 11-week study period than did the wild-type controls....
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