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Article

Epilepsy and obesity in serotonin 5-HT2C receptor mutant mice.

Annals of the New York Academy of Sciences - 15 Dec 1998

Heisler L K, Chu H M, Tecott L H

Abstract excerpt

Serotonin 5-HT2C receptor null mutant mice were generated to assess the contribution of this receptor to the actions of serotonin. Mutant mice displayed both an epilepsy and obesity phenotype. The epilepsy syndrome was characterized by spontaneous seizures, lowered seizure threshold, enhanced seizure propagation and sound-induced seizure susceptibility. These findings implicate 5-HT2C receptors in the regulation...

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Source

Identifiers

PMID: 9928241
DOI: 10.1111/j.1749-6632.1998.tb10175.x

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