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Article

Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene.

Obesity (Silver Spring, Md.) - 1 Oct 2010

Nicholson Anthony, Reifsnyder Peter C, Malcolm Rachel D, Lucas Charlotte A, MacGregor Grant R, Zhang Weidong, Leiter Edward H

Abstract excerpt

The C57BL/6J (B6/J) male mouse represents a standard for diet-induced obesity (DIO) and is unique in expressing a loss-of-function nicotinamide nucleotide transhydrogenase (Nnt) gene. This mutation was associated with a marked reduction in glucose-stimulated insulin secretion from B6/J islets in...

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Identifiers

PMID: 20057372
DOI: 10.1038/oby.2009.477
PMCID: PMC2888716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20057372-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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