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Article

Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2005

Kokkotou Efi, Jeon Justin Y, Wang Xiaomei, Marino Francis E, Carlson Michael, Trombly Daniel J, Maratos-Flier Eleftheria

Abstract excerpt

Genetics and environment contribute to the development of obesity, in both humans and rodents. However, the potential interaction between genes important in energy balance, strain background, and dietary environment has been only minimally explored. We investigated the effects of genetic ablation of melanin-concentrating hormone (MCH), a neuropeptide with a key role in energy balance, with chow and a high-fat...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15731402
DOI: 10.1152/ajpregu.00861.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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