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Article

A Dominant Role for p53-Dependent Cellular Senescence in Radiosensitization of Human Prostate Cancer Cells

1 Mar 2007

Abstract excerpt

Because p53 inactivation may limit the effectiveness of radiation therapy for localized prostate cancer, it is important to understand how this gene regulates clonogenic survival after an exposure to ionizing radiation. Here, we show that premature cellular senescence is the principal mode of cell death accounting for the radiosensitivity of human prostate cancer cell lines retaining p53 function. Alternative...

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Share to Cancer-related Molecular Pathways
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Identifiers

PMID: 17351335
DOI: 10.4161/cc.6.5.3901

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