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Article

Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006

Messaoudi Ilhem, Warner Jessica, Nikolich-Zugich Janko

Abstract excerpt

Aging is accompanied by numerous changes in T cell biology. Among the most dramatic changes at the population level are the appearance and persistence of CD8+ T cell clonal expansions (TCE), whose frequency increases steadily with age, and whose biology is incompletely understood. In this study, we examined trafficking, phenotypic makeup, and homeostatic responsiveness of TCE, which arise spontaneously in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16920913
DOI: 10.4049/jimmunol.177.5.2784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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