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Effects of oxygen on mouse embryonic stem cell growth, phenotype retention, and cellular energetics.

Biotechnology and bioengineering - 1 Oct 2008

Powers Daryl E, Millman Jeffrey R, Huang Ryan B, Colton Clark K

Abstract excerpt

Most embryonic stem (ES) cell research is performed with a gas phase oxygen partial pressure (pO(2)) of 142 mmHg, whereas embryonic cells in early development are exposed to pO(2) values of 0-30 mmHg. To understand effects of these differences, we studied murine ES (mES) growth, maintenance of stem cell phenotype, and cell energetics over a pO(2) range of 0-285 mmHg, in the presence or absence of...

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PMID: 18727033
DOI: 10.1002/bit.21986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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