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Oxygen modulates human embryonic stem cell metabolism in the absence of changes in self-renewal.

Reproduction, fertility, and development - 1 Mar 2016

Harvey Alexandra J, Rathjen Joy, Yu Lijia Jackie, Gardner David K

Abstract excerpt

Human embryonic stem (ES) cells are routinely cultured under atmospheric oxygen (~20%), a concentration that is known to impair embryo development in vitro and is likely to be suboptimal for maintaining human ES cells compared with physiological (~5%) oxygen conditions. Conflicting reports exist on the effect of oxygen during human ES cell culture and studies have been largely limited to characterisation of...

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PMID: 25145274
DOI: 10.1071/RD14013

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