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Article

The role of oxygen availability in embryonic development and stem cell function.

Nature reviews. Molecular cell biology - 1 Apr 2008

Simon M Celeste, Keith Brian

Abstract excerpt

Low levels of oxygen (O2) occur naturally in developing embryos. Cells respond to their hypoxic microenvironment by stimulating several hypoxia-inducible factors (and other molecules that mediate O2 homeostasis), which then coordinate the development of the blood, vasculature, placenta, nervous system and other organs. Furthermore, embryonic stem and progenitor cells frequently occupy hypoxic 'niches' and low O2...

Topics

Animals
Cell Hypoxia
Embryonic Development
Humans
Oxygen
Phenotype
Stem Cells

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18285802
DOI: 10.1038/nrm2354
PMCID: PMC2876333

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