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Article

Interplay between the gamma isoform of PKC and calcineurin in regulation of vulnerability to focal cerebral ischemia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Feb 2000

Aronowski J, Grotta J C, Strong R, Waxham M N

Abstract excerpt

Protein phosphorylation and dephosphorylation mediated by protein kinases and protein phosphatases, respectively, represent essential steps in a variety of vital neuronal processes that could affect susceptibility to ischemic stroke. In this study, the role of the neuron-specific gamma isoform of...

Topics

Animals
Brain
Brain Ischemia
Calcineurin
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Female
Gene Expression Regulation, Enzymologic
Genetic Predisposition to Disease
Immunosuppressive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infarction, Middle Cerebral Artery

Isoenzymes

Male

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Knockout

Phosphorylation

Source

Identifiers

PMID: 10698072
DOI: 10.1097/00004647-200002000-00016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10698072-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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