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Article

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.

Nature neuroscience - 1 Oct 2003

Wang Jian, Liu ShuHong, Fu YangPing, Wang Jerry H, Lu YouMing

Abstract excerpt

CA1 pyramidal neurons degenerate after transient forebrain ischemia, whereas neurons in other regions of the hippocampus remain intact. Here we show that in rat hippocampal CA1 neurons, forebrain ischemia induces the phosphorylation of the N-methyl-D-aspartate (NMDA) receptor 2A subunit at Ser1232 (phospho-Ser1232). Ser1232 phosphorylation is catalyzed by cyclin-dependent kinase 5 (Cdk5). Inhibiting endogenous...

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PMID: 14502288
DOI: 10.1038/nn1119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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