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Article

Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits.

Obesity (Silver Spring, Md.) - 1 Oct 2008

Meigs James B, Manning Alisa K, Dupuis Josée, Liu Chunyu, Florez Jose C, Cupples L Adrienne

Abstract excerpt

Phenotypic heterogeneity complicates detection of genomic loci predisposing to type 2 diabetes, potentially obscuring or unmasking specific loci. We conducted ordered-subsets linkage analyses (OSAs) for diabetes-related quantitative traits (fasting insulin and glucose, hemoglobin A1c (HbA1c), and 28-year-time-averaged fasting plasma glucose (FPG)) from 330 families of the Framingham Offspring Study. We calculated...

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Identifiers

PMID: 18719643
DOI: 10.1038/oby.2008.354
PMCID: PMC3747653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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