Article
Early adult-onset POAG linked to 15q11-13 using ordered subset analysis.
Investigative ophthalmology & visual science - 1 Jun 2005
Allingham R Rand, Wiggs Janey L, Hauser Elizabeth R, Larocque-Abramson Karen R, Santiago-Turla Cecilia, Broomer Bob, Del Bono Elizabeth A, Graham Felicia L, Haines Jonathan L, Pericak-Vance Margaret A, Hauser Michael A
Abstract excerpt
PURPOSE: Primary open-angle glaucoma (POAG) is a complex inherited disorder. It has been demonstrated in other complex disorders that phenotypic heterogeneity may be the result of genetic heterogeneity and that stratification analysis can be used to increase the power of detection. Ordered subset analysis (OSA) is a recently described method that utilizes the variability of phenotypic traits to determine...
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