Article
A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13.
The Journal of clinical endocrinology and metabolism - 1 May 2003
van Tilburg J H O, Sandkuijl L A, Strengman E, van Someren H, Rigters-Aris C A E, Pearson P L, van Haeften T W, Wijmenga C
Abstract excerpt
A genome-wide scan was performed, using nonparametric linkage analyses, to find susceptibility loci for type 2 diabetes mellitus in the Dutch population. We studied 178 families from The Netherlands, who constituted 312 affected sibling pairs. The first stage of the genome scan consisted of 270 DNA markers, with an average intermarker spacing of 13 cM. Because obesity and type 2 diabetes mellitus are...
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