Article
Application of an ordered subset analysis approach to the genetics of alcoholism.
Genetic epidemiology - 1 Jan 1999
Watanabe R M, Ghosh S, Birznieks G, Duren W L, Mitchell B D
Abstract excerpt
For complex diseases, underlying etiologic heterogeneity may reduce power to detect linkage. Thus, methods to identify more homogeneous subgroups within a given sample in a linkage study may improve detection of putative susceptibility loci. In this study we describe an ordered subsetting approach that utilizes disease-related quantitative trait data to complement traditional linkage analysis. This approach uses...
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