Article
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.
Ageing research reviews - 1 Jan 2017
de Renty Christelle, Ellis Nathan A
Abstract excerpt
Genomic instability is a hallmark of cancer and aging. Premature aging (progeroid) syndromes are often caused by mutations in genes whose function is to ensure genomic integrity. The RecQ family of DNA helicases is highly conserved and plays crucial roles as genome caretakers. In humans, mutations in three RecQ genes - BLM, WRN, and RECQL4 - give rise to Bloom's syndrome (BS), Werner syndrome (WS), and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.