Article
Role of the Bloom's syndrome helicase in maintenance of genome stability.
Biochemical Society transactions - 1 May 2001
Hickson I D, Davies S L, Li J L, Levitt N C, Mohaghegh P, North P S, Wu L
Abstract excerpt
The RecQ family of DNA helicases has members in all organisms analysed. In humans, defects in three family members are associated with disease conditions: BLM is defective in Bloom's syndrome, WRN in Werner's syndrome and RTS in Rothmund-Thomson syndrome. In each case, cells from affected individuals show inherent genomic instability. The focus of our work is the Bloom's syndrome gene and its product, BLM. Here,...
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