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Article

Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008

Katz Chen, Benyamini Hadar, Rotem Shahar, Lebendiker Mario, Danieli Tsafi, Iosub Anat, Refaely Hadar, Dines Monica, Bronner Vered, Bravman Tsafrir, Shalev Deborah E, Rüdiger Stefan, Friedler Assaf

Abstract excerpt

We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic pathway. The C-terminal ankyrin repeats and SH3 domain of ASPP2 (ASPP2(Ank-SH3)) mediate its interactions with the antiapoptotic protein Bcl-2. We used biophysical and computational methods to identify the interaction sites of Bcl-2 and its homologues with ASPP2. Using peptide array...

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Identifiers

PMID: 18719108
DOI: 10.1073/pnas.0711269105
PMCID: PMC2527902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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