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Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review

23 Dec 2011

Abstract excerpt

INTRODUCTION: The B-cell lymphoma-2 (Bcl-2) family of proteins is central to the regulation of apoptosis, which is vital for proper tissue development and cellular homeostasis. Anti-apoptotic proteins, members of the Bcl-2 family, are an important survival factor for many cancers and their overexpression has been associated with tumor initiation, progression, and resistance to current anticancer therapies....

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PMID: 22195752
DOI: 10.1517/13543776.2012.644274

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