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Article

Binding modes of Bcl-2 homology 3 (BH3) peptides with anti-apoptotic protein A1 and redesign of peptide inhibitors: a computational study.

Journal of biomolecular structure & dynamics - 1 Nov 2018

Chen Yantao, Wang Jun, Zhang Jian, Wang Wei

Abstract excerpt

The interaction between protein and peptide ligand is a challenging problem in molecular biology and drug design. The binding of the Bcl-2 homology 3 (BH3) peptide to the anti-apoptotic protein A1 was revealed as a critical step in the regulation of apoptosis. These BH3 peptides hold high structural similarity, but are diverse in their regulation abilities. Based on molecular simulations and MM-P(G)BSA methods,...

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Source

Identifiers

PMID: 29137527
DOI: 10.1080/07391102.2017.1404933

Genes

BMF

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Binding modes of Bcl-2 homology 3 (BH3) peptides with anti-apoptotic protein A1 and redesign of peptide inhibitors: a computational study.PMID 29137527Read ↗

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