Article
Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain.
Scientific reports - 15 Apr 2015
Vervliet Tim, Lemmens Irma, Vandermarliere Elien, Decrock Elke, Ivanova Hristina, Monaco Giovanni, Sorrentino Vincenzo, Nadif Kasri Nael, Missiaen Ludwig, Martens Lennart, De Smedt Humbert, Leybaert Luc, Parys Jan B, Tavernier Jan, Bultynck Geert
Abstract excerpt
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca(2+)-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), while Bcl-XL, likely independently of its BH4 domain, sensitizes IP3Rs. It remains elusive whether Bcl-XL can also target and modulate RyRs. Here, Bcl-XL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.