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Article

Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line.

Molecular immunology - 1 Nov 2008

Chezar Ilan, Lobel-Lavi Liat, Steinitz Michael, Laskov Reuven

Abstract excerpt

Epstein-Barr virus (EBV) transforms human peripheral B cells into lymphoblastoid cell lines (LCLs) that secrete specific antibodies. In contrast to peripheral blood B cells, LCLs express the activation-induced cytidine deaminase (AID) gene, a key enzyme in the generation of somatic hypermutation (SHM) in immunoglobulin variable genes. We have previously studied an LCL that secretes a rheumatoid factor (RF: an...

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Share to Cell Transformation, Viral
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin lambda-Chains

Share to MutS Homolog 2 Protein

Share to Proto-Oncogene Proteins c-bcl-6

Share to Rheumatoid Factor

Share to Somatic Hypermutation, Immunoglobulin

Share to Uracil-DNA Glycosidase

Source

Identifiers

PMID: 18718665
DOI: 10.1016/j.molimm.2008.07.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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