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Article

Epstein-Barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology.

PLoS pathogens - 1 Jan 2012

Heath Emily, Begue-Pastor Noelia, Chaganti Sridhar, Croom-Carter Debbie, Shannon-Lowe Claire, Kube Dieter, Feederle Regina, Delecluse Henri-Jacques, Rickinson Alan B, Bell Andrew I

Abstract excerpt

Epstein-Barr virus (EBV), a lymphomagenic human herpesvirus, colonises the host through polyclonal B cell-growth-transforming infections yet establishes persistence only in IgD⁺ CD27⁺ non-switched memory (NSM) and IgD⁻ CD27⁺ switched memory (SM) B cells, not in IgD⁺ CD27⁻ naïve (N) cells. How this selectivity is achieved remains poorly understood. Here we show that purified N, NSM and SM cell preparations are...

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Identifiers

PMID: 22589726
DOI: 10.1371/journal.ppat.1002697
PMCID: PMC3349760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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