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Article

Somatic mutations and activation-induced cytidine deaminase (AID) expression in established rheumatoid factor-producing lymphoblastoid cell line.

Molecular immunology - 1 Jan 2007

Gil Yaniv, Levy-Nabot Sarah, Steinitz Michael, Laskov Reuven

Abstract excerpt

Epstein-Barr virus (EBV) transforms human peripheral B cells into lymphoblastoid cell lines (LCLs), allowing the production of specific antibody-secreting cell lines. We and others have previously found that in contrast to peripheral blood B cells, EBV-transformed lymphoblastoid cell lines express the activation-induced cytidine deaminase (AID) gene. The opposite is true for the germinal center-specific BCL6...

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Topics

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Share to Cell Transformation, Viral
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epstein-Barr Virus Infections

Share to Gene Rearrangement, B-Lymphocyte

Share to Herpesvirus 4, Human

Share to Immunoglobulin Variable Region

Share to Rheumatoid Factor

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 16574227
DOI: 10.1016/j.molimm.2006.02.012

Genes

BCL6
GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Somatic mutations and activation-induced cytidine deaminase (AID) expression in established rheumatoid factor-producing lymphoblastoid cell line.PMID 16574227Read ↗

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