Article
Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.
The EMBO journal - 17 Sept 2008
Kwapisz Marta, Wery Maxime, Després Daphné, Ghavi-Helm Yad, Soutourina Julie, Thuriaux Pierre, Lacroute François
Abstract excerpt
The yeast URA2 gene, encoding the rate-limiting enzyme of UTP biosynthesis, is transcriptionally activated by UTP shortage. In contrast to other genes of the UTP pathway, this activation is not governed by the Ppr1 activator. Moreover, it is not due to an increased recruitment of RNA polymerase II at the URA2 promoter, but to its much more effective progression beyond the URA2 mRNA start site(s). Regulatory...
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