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Article

Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans.

Experimental gerontology - 1 Aug 2014

Rooney J P, Luz A L, González-Hunt C P, Bodhicharla R, Ryde I T, Anbalagan C, Meyer J N

Abstract excerpt

5-Fluoro-2'-deoxyuridine (FUdR) is a DNA synthesis inhibitor commonly used to sterilize Caenorhabditis elegans in order to maintain a synchronized aging population of nematodes, without contamination by their progeny, in lifespan experiments. All somatic cells in the adult nematode are post-mitotic and therefore do not require nuclear DNA synthesis. However, mitochondrial DNA (mtDNA) replicates independently of...

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Identifiers

PMID: 24704715
DOI: 10.1016/j.exger.2014.03.021
PMCID: PMC4048797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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